Lymphoma Learning Quizzes: Test Your Knowledge

Question 1

In the diagnosis of lymphoma, which immunohistochemical stain is specifically used to distinguish Hodgkin lymphoma from non-Hodgkin lymphoma?

Accepted Answer

CD30

Answer

CD20

Answer

CD3

Answer

CD68

Question 2

Among the different stages of lymphoma, which stage is associated with the most favorable five-year survival rate?

Accepted Answer

Stage I

Answer

Stage II

Answer

Stage III

Answer

Stage IV

Question 3

Which of the following is NOT a hallmark of lymphoma?

Accepted Answer

Exclusive involvement of peripheral lymph nodes

Answer

Neoplastic proliferation of lymphocytes

Answer

Origin in lymphoid tissue

Answer

Presence of immature lymphocytes

Question 4

According to the World Health Organization (WHO) classification, which of the following is NOT a subtype of non-Hodgkin lymphoma?

Accepted Answer

Hodgkin's lymphoma

Answer

Diffuse large B-cell lymphoma

Answer

Follicular lymphoma

Answer

Mantle cell lymphoma

Question 5

Which of the following molecular abnormalities is commonly associated with follicular lymphoma?

Accepted Answer

t(11;14)

Answer

t(8;14)

Answer

t(14;18)

Answer

MYC amplification

Question 6

A patient presents with painless, progressively enlarging axillary lymph nodes. Which of the following diagnostic tests is most appropriate to confirm the diagnosis of lymphoma?

Accepted Answer

Fine needle aspiration biopsy

Answer

Chest X-ray

Answer

Bone marrow biopsy

Answer

CT scan of the abdomen

Question 7

Which of the following is NOT a risk factor for Hodgkin's lymphoma?

Accepted Answer

Advanced age

Answer

Epstein-Barr virus infection

Answer

HIV infection

Answer

Family history of lymphoma

Question 8

In the Lugano staging system for non-Hodgkin lymphomas, which stage indicates involvement of both lymph node regions above the diaphragm?

Accepted Answer

Stage III

Answer

Stage I

Answer

Stage II

Answer

Stage IV

Question 9

Which of the following is a preferred first-line treatment option for aggressive B-cell non-Hodgkin lymphomas?

Accepted Answer

R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)

Answer

Radiation therapy

Answer

Pembrolizumab (Keytruda)

Answer

Autologous stem cell transplantation

Question 10

Which of the following is the most prevalent type of lymphoma?

Accepted Answer

Non-Hodgkin lymphoma

Answer

Hodgkin lymphoma

Answer

Lymphoblastic leukemia

Answer

Myeloid leukemia

Question 11

What is the most typical initial symptom of lymphoma?

Accepted Answer

Enlarged lymph nodes

Answer

Fever

Answer

Weight loss

Answer

Night sweats

Question 12

Which diagnostic test is commonly used to confirm lymphoma?

Accepted Answer

Tissue biopsy

Answer

Chest X-ray

Answer

Blood test

Answer

Urine test

Question 13

For most cases of Hodgkin lymphoma, what is the primary treatment approach?

Accepted Answer

Chemotherapy

Answer

Radiation therapy

Answer

Surgery

Answer

Immunotherapy

Question 14

What distinctive histologic feature is characteristic of Hodgkin lymphoma?

Accepted Answer

Reed-Sternberg cells

Answer

Hodgkin cells

Answer

Mononuclear cells

Answer

Multinucleated cells

Question 15

What histologic feature is characteristic of Hodgkin lymphoma?

Accepted Answer

Reed-Sternberg cells

Answer

Centroblasts and immunoblasts

Answer

Mantle zone expansion

Answer

Follicular hyperplasia

Question 16

What is the definitive diagnostic procedure for lymphoma?

Accepted Answer

Lymph node biopsy

Answer

Physical examination

Answer

Blood test

Answer

Bone marrow biopsy

Question 17

Which treatment regimen is commonly used as first-line therapy for diffuse large B-cell lymphoma?

Accepted Answer

Rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone (R-CHOP)

Answer

Fludarabine-cyclophosphamide-mitoxantrone (FCM)

Answer

Bendamustine-rituximab (BR)

Answer

Ibrutinib-rituximab (IR)

Question 18

Which of the following is a hallmark characteristic of Hodgkin lymphoma?

Accepted Answer

Presence of Reed-Sternberg cells

Answer

Diffuse architecture

Answer

Common in extranodal sites

Answer

Lymphocyte-predominant pattern

Question 19

Which subtype of non-Hodgkin lymphoma is the most prevalent globally?

Accepted Answer

Diffuse large B-cell lymphoma

Answer

Marginal zone lymphoma

Answer

Mantle cell lymphoma

Answer

Follicular lymphoma

Question 20

Which of the following is the most common initial symptom experienced by individuals with lymphoma?

Accepted Answer

Swollen lymph nodes

Answer

Fatigue

Answer

Night sweats

Answer

Fever

Question 21

Which imaging technique is considered the most informative for diagnosing lymphoma?

Accepted Answer

Computed tomography (CT) scan

Answer

Magnetic resonance imaging (MRI)

Answer

X-ray

Answer

Ultrasound

Question 22

In the treatment of aggressive non-Hodgkin lymphoma, which regimen is typically employed as the frontline approach?

Accepted Answer

R-CHOP chemotherapy

Answer

Immunotherapy

Answer

Targeted therapy

Answer

Radiation therapy

Question 23

For patients with diffuse large B-cell lymphoma, what is the approximate 5-year survival rate?

Accepted Answer

Approximately 70%

Answer

Approximately 90%

Answer

Less than 20%

Answer

Approximately 40%

Question 24

In the context of lymphoma treatment, what is the primary role of stem cell transplantation?

Accepted Answer

A potential curative option for refractory or relapsed disease

Answer

Standard first-line therapy for all lymphoma subtypes

Answer

Not an effective treatment modality for lymphoma

Answer

Exclusively used for patients with indolent lymphomas

Question 25

Select the most important risk factor for the development of lymphoma:

Accepted Answer

Weakened immune system

Answer

Exposure to sunlight

Answer

Smoking

Answer

Obesity

Question 26

Which imaging modality is typically employed as the initial diagnostic tool for lymphoma?

Accepted Answer

CT scan

Answer

Ultrasound

Answer

X-ray

Answer

MRI

Question 27

Which treatment regimen is considered the first-line approach for diffuse large B-cell lymphoma?

Accepted Answer

R-CHOP

Answer

ABVD

Answer

BEAM

Answer

CVP

Question 28

Which histological subtype is characteristic of Hodgkin lymphoma?

Accepted Answer

Nodular sclerosis

Answer

Burkitt

Answer

Diffuse large B-cell

Question 29

Select the factor that is associated with a positive prognosis in patients diagnosed with lymphoma:

Accepted Answer

Early stage

Answer

Poor performance status

Answer

High tumor burden

Answer

Advanced age

Question 30

Which of the following is the most common primary extranodal site for non-Hodgkin lymphoma?

Accepted Answer

Gastrointestinal tract

Answer

Brain

Answer

Bone

Answer

Skin

Question 31

Which of the following cell types is characteristic of Hodgkin lymphoma?

Accepted Answer

Reed-Sternberg cells

Answer

Plasma cells

Answer

B cells

Answer

T cells

Question 32

Which of the following is a risk factor for the development of Burkitt lymphoma?

Accepted Answer

Epstein-Barr virus infection

Answer

Autoimmune disorders

Answer

Radiation exposure

Answer

Smoking

Question 33

Which of the following laboratory tests is used to confirm the diagnosis of lymphoma?

Accepted Answer

Flow cytometry

Answer

Urinalysis

Answer

Complete blood count

Answer

Liver function tests

Question 34

Which characteristic feature is unique to mantle cell lymphoma?

Accepted Answer

Expression of cyclin D1

Answer

Presence of Reed-Sternberg cells

Answer

Frequent involvement of the spleen

Answer

Association with Epstein-Barr virus

Question 35

In patients with advanced-stage Hodgkin lymphoma, which treatment modality is considered the primary approach?

Accepted Answer

Chemotherapy

Answer

Immunotherapy

Answer

Radiation therapy

Answer

Surgery

Question 36

Splenectomy, a surgical procedure sometimes used in lymphoma treatment, carries the potential for a life-threatening complication. Which of the following is this complication?

Accepted Answer

Overwhelming post-splenectomy infection (OPSI)

Answer

Thromboembolism

Answer

Lymphedema

Answer

Ascites

Question 37

Follicular lymphoma exhibits a varied prognosis, influenced by the stage of the disease at diagnosis. Which of the following accurately describes the prognosis for patients with early-stage follicular lymphoma?

Accepted Answer

Excellent prognosis

Answer

Poor prognosis regardless of stage

Answer

Poor prognosis

Answer

Excellent prognosis regardless of stage

Question 38

Among the established risk factors associated with the development of lymphoma, which of the following stands out as a major contributor?

Accepted Answer

Immunosuppression

Answer

Exposure to sunlight

Answer

Diabetes

Answer

Obesity

Question 39

A 55-year-old male presents with painless, enlarged lymph nodes in the cervical and supraclavicular regions. A biopsy reveals a diffuse, large cell lymphoma. Which subtype of lymphoma is the most likely diagnosis in this case?

Accepted Answer

Diffuse large B-cell lymphoma (DLBCL)

Answer

Mantle cell lymphoma

Answer

Hodgkin lymphoma

Answer

Follicular lymphoma

Question 40

Hodgkin lymphoma is characterized by specific histological features. Which of the following is a hallmark of Hodgkin lymphoma?

Accepted Answer

Presence of Reed-Sternberg cells

Answer

Typically presents with extranodal involvement

Answer

More common in younger patients

Answer

Diffuse involvement of lymph nodes

Question 41

A 60-year-old female with a history of follicular lymphoma presents with progressive fatigue and anemia. Which of the following is the most plausible explanation for these symptoms?

Accepted Answer

Bone marrow involvement

Answer

Autoimmune complications

Answer

Drug toxicity from chemotherapy

Answer

Infectious complications

Question 42

A 25-year-old male presents with a rapidly enlarging mediastinal mass. A biopsy reveals a lymphoma with a high mitotic index and expression of CD30. What is the most likely diagnosis?

Accepted Answer

Anaplastic large cell lymphoma (ALCL)

Answer

Lymphoblastic lymphoma

Answer

Diffuse large B-cell lymphoma

Answer

Burkitt lymphoma

Question 43

A 70-year-old female with a history of chronic lymphocytic leukemia (CLL) develops progressive fatigue, weight loss, and recurrent infections. Which of the following is the most likely cause of these symptoms?

Accepted Answer

Transformation to Richter's syndrome

Answer

Drug toxicity from chemotherapy

Answer

Autoimmune hemolytic anemia

Answer

Progression of CLL

Question 44

Which of the following is the cornerstone of treatment for most lymphoma subtypes?

Accepted Answer

Chemotherapy

Answer

Radiation therapy

Answer

Immunotherapy

Answer

Stem cell transplantation

Question 45

A 35-year-old female with a history of follicular lymphoma is being monitored for disease progression. Which of the following is the MOST effective imaging modality for detecting early recurrence?

Accepted Answer

PET-CT scan

Answer

Ultrasound

Answer

Computed tomography (CT) scan

Answer

Magnetic resonance imaging (MRI)

Question 46

Which of the following is a characteristic of Hodgkin lymphoma?

Accepted Answer

Reed-Sternberg cells

Answer

Burkitt-type cells

Answer

Immunoblasts

Answer

Centroblasts

Question 47

Which of the following is a risk factor for the development of lymphoma?

Accepted Answer

Immunosuppression

Answer

Smoking

Answer

Physical activity

Answer

Obesity

Question 48

What is the characteristic histological feature of follicular lymphoma?

Accepted Answer

Follicular growth pattern with centroblasts and centrocytes

Answer

Nodular growth pattern with Reed-Sternberg cells

Answer

Diffuse growth pattern with large lymphoid cells

Question 49

Which of the following imaging modalities is most useful for staging lymphoma?

Accepted Answer

PET-CT scan

Answer

Ultrasound

Answer

MRI

Answer

X-ray

Question 50

What is the initial treatment of choice for most patients with diffuse large B-cell lymphoma?

Accepted Answer

R-CHOP chemotherapy

Answer

Targeted therapy

Answer

Surgery

Answer

Radiation therapy

Question 51

What is the prognosis for patients with early-stage Hodgkin lymphoma?

Accepted Answer

Excellent

Answer

Good

Answer

Fair

Question 52

Which of the following is a type of cutaneous lymphoma?

Accepted Answer

Mycosis fungoides

Answer

Burkitt lymphoma

Answer

Follicular lymphoma