Cell-Biomaterial Interactions: A Comprehensive Guide for Biotechnology Students

Question 1

What is the **primary function** of integrins in cell-biomaterial interactions?

Accepted Answer

Mediating cell attachment to the biomaterial surface

Answer

Activating intracellular signaling pathways

Answer

Regulating cell differentiation

Answer

Inhibiting cell proliferation

Question 2

Which term describes the process by which cells **alter their destiny or function** in response to biomaterials?

Accepted Answer

Differentiation

Answer

Transdifferentiation

Answer

Dedifferentiation

Answer

Metaplasia

Question 3

What is the **utmost** significance of biocompatibility in cell-biomaterial interactions?

Accepted Answer

Ensuring that the biomaterial does not elicit adverse reactions in the body

Answer

Promoting cell adhesion and proliferation

Answer

Preventing the formation of a fibrous capsule around the biomaterial

Answer

Enhancing the mechanical properties of the biomaterial

Question 4

Which of the following **applications** of cell-biomaterial interactions holds the **greatest promise** in regenerative medicine?

Accepted Answer

Tissue engineering

Answer

Drug delivery

Answer

Biosensors

Answer

Bioimaging

Question 5

Which type of cell adhesion involves direct binding of integrins to specific proteins on the biomaterial surface?

Accepted Answer

Specific binding

Answer

Covalent binding

Answer

Non-specific binding

Answer

Weak binding

Question 6

Which cell differentiation pathway is commonly associated with osteoblast differentiation on biomaterials?

Accepted Answer

BMP signaling

Answer

Wnt signaling

Answer

TGF-β signaling

Answer

Notch signaling

Question 7

Which of the following is a potential application of cell-biomaterial interactions in tissue engineering?

Accepted Answer

Tissue engineering scaffolds

Answer

Drug delivery systems

Answer

Biosensors

Answer

Cancer treatments

Question 8

Which type of biomaterial is commonly used in orthopedic implants due to its excellent biocompatibility and osteoconductive properties?

Accepted Answer

Hydroxyapatite

Answer

Titanium

Answer

Polystyrene

Answer

Carbon fiber

Question 9

The process by which cells acquire specialized functions in response to cues from the biomaterial is known as:

Accepted Answer

Cell differentiation

Answer

Cell migration

Answer

Cell signaling

Answer

Cell activation

Question 10

Which of the following biomaterials is commonly used in bone regeneration applications?

Accepted Answer

Hydroxyapatite

Answer

Polylactic acid

Answer

Polyethylene

Answer

Polyurethane

Question 11

The ability of biomaterials to guide cell behavior is known as:

Accepted Answer

Bioactivity

Answer

Biocompatibility

Answer

Biodegradation

Answer

Biomechanics

Question 12

Which technique is commonly used to characterize cell-biomaterial interactions at a molecular level?

Accepted Answer

Proteomics

Answer

Immunohistochemistry

Answer

Scanning electron microscopy

Answer

Transmission electron microscopy

Question 13

Which of the following biomaterials is widely recognized for its exceptional biocompatibility?

Accepted Answer

Titanium

Answer

Polylactic acid

Answer

Polyurethane

Answer

Polyethylene

Question 14

Which type of cell-biomaterial interaction involves the formation of a strong and stable bond between the cell and the biomaterial?

Accepted Answer

Integration

Answer

Adsorption

Answer

Anchorage

Answer

Detachment

Question 15

How can the surface topography of biomaterials contribute to cell proliferation?

Accepted Answer

It can alter cell shape and influence cytoskeletal organization.

Answer

It can provide microscale cues that guide cell migration.

Answer

It can release bioactive molecules that stimulate cell growth.

Answer

It has no effect on cell proliferation.

Question 16

Which of the following best describes the primary function of integrins in cell adhesion to biomaterials?

Accepted Answer

Integrins serve as receptors that bind to specific molecules on the biomaterial's surface, facilitating cell attachment and spreading.

Answer

Integrins are primarily involved in cell-cell adhesion and have no significant role in cell adhesion to biomaterials.

Answer

Integrins regulate cell proliferation and differentiation but have no direct involvement in cell adhesion to biomaterials.

Answer

Integrins are not necessary for cell adhesion to biomaterials.

Question 17

Which surface property of a biomaterial plays a crucial role in promoting cell adhesion?

Accepted Answer

Hydrophilicity (water-loving)

Answer

Smoothness

Answer

Crystallinity

Answer

Lipophilicity (oil-loving)

Question 18

The term that describes the process by which cells attach to and spread on a biomaterial is:

Accepted Answer

Cell adhesion

Answer

Cell proliferation

Answer

Cell migration

Answer

Cell differentiation

Question 19

Which of the following biomaterials serves as a common substrate for cell culture?

Accepted Answer

Polystyrene

Answer

Hydroxyapatite

Answer

Polycarbonate

Answer

Polyethylene terephthalate

Question 20

The ability of a biomaterial to support cell proliferation is influenced by its:

Accepted Answer

Chemistry and topography

Answer

Size and shape

Answer

Mechanical properties

Answer

Electrical properties

Question 21

In tissue engineering, which type of cell differentiation is typically desired?

Accepted Answer

Directed differentiation

Answer

Transdifferentiation

Answer

Spontaneous differentiation

Answer

Metaplasia

Question 22

The term 'biocompatibility' refers to the ability of a biomaterial to:

Accepted Answer

Elicit a favorable response from living tissue

Answer

Withstand high temperatures

Answer

Resist bacterial colonization

Answer

Degrade within a controlled time frame

Question 23

Which technique is commonly used to visualize and characterize the interactions between cells and biomaterials?

Accepted Answer

Scanning electron microscopy (SEM)

Answer

Immunohistochemistry

Answer

Polymerase chain reaction (PCR)

Answer

Western blotting

Question 24

The primary goal of using biomaterials in regenerative medicine is to:

Accepted Answer

Repair or replace damaged tissues and organs

Answer

Detect and diagnose diseases

Answer

Improve physical performance

Answer

Enhance drug delivery

Question 25

When designing biomaterials for tissue engineering, which of the following factors is typically NOT considered?

Accepted Answer

Patient aesthetics

Answer

Biocompatibility

Answer

Biodegradability

Answer

Mechanical properties